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Letrozole is primarily used to treat specific types of breast cancer, such as hormone receptor-positive breast cancer, in postmenopausal women. It may also be prescribed for other conditions as determined by a healthcare provider.
Letrozole is an aromatase inhibitor that reduces estrogen production by blocking the aromatase enzyme. Since certain breast cancers rely on estrogen to grow, decreasing its levels helps slow or stop tumor growth.
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✅ Description:
Changes in the breasts or nipples should never be ignored as they may indicate breast cancer. Common symptoms include:
- Lumps in the breast or armpit
- Pain in the breast or nipple
- Changes in the size, shape, or appearance of the breast
- Nipple discharge or bleeding
- Inverted or painful nipples
- Skin dimpling or folds on the breast skin
- Swollen lymph nodes in the underarms or around the collarbone
Breast cancer develops when cells in the breast tissue (lobules or ducts) grow uncontrollably, potentially spreading to nearby tissue and lymph nodes.
Commonly affected: Adults above 40 years, more frequent in women but can also occur in men and children (rarely).
Diagnosis and Screening
Breast cancer cannot be prevented but can be detected early through:
- Blood tests: CA 15.3 and CA 27.29 (breast cancer markers).
- Imaging tests: Mammography, MRI mammograms.
Early detection improves the chances of successful treatment and management.
Treatment Options
Treatment depends on the stage and severity of the cancer and may involve:
Surgery:
- Lumpectomy: Removal of a lump or part of the breast tissue.
- Mastectomy: Removal of the entire breast.
- Breast reconstruction therapy.
Medications:
- Chemotherapy: Cyclophosphamide, Fluorouracil, Gemcitabine.
- Hormonal Therapy: Tamoxifen, Fulvestrant, Letrozole, Megestrol.
- Targeted Therapy: Trastuzumab, Pertuzumab, Neratinib.
- Immunotherapy: Pembrolizumab, Atezolizumab.
Radiation Therapy: High-energy radiation to destroy cancer cells.
Risk Factors for Breast Cancer
Genetic Factors (5-10% cases):
- BRCA1 and BRCA2 gene mutations significantly increase breast cancer risk (26-84%).
Other Risk Factors (90% sporadic cases):
- Gender: Women are more prone than men.
- Risk increases after age 50.
- Personal history of breast cancer or other breast conditions (e.g., lobular carcinoma in situ).
- Family history of breast or ovarian cancer.
- Early menarche (before 12 years) or late menopause (after 55 years).
- Hormone replacement therapy after menopause.
- Never being pregnant or having the first child after 30.
- Lifestyle Factors:
- Smoking and alcohol consumption.
- Obesity or a sedentary lifestyle.
- Others:
- Radiation exposure to the head, neck, or chest.
- Dense breast tissue.
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✔️ Side Effects of Letrozole
Common side effects:
If any of these side effects persist or worsen, inform your healthcare provider:
- Hot flashes, flushing, or increased sweating
- Fatigue or lack of energy
- Bone, joint, or muscle pain
- High cholesterol levels
- Fluid retention
- Dizziness or headache
Serious side effects:
Although rare, Letrozole may cause serious side effects. Seek immediate medical attention if you experience:
- Severe allergic reactions (e.g., breathing difficulty, rash, swelling of the face, lips, or throat)
- Weakened bones (osteopenia or osteoporosis) leading to fractures
- Elevated cholesterol levels
Contact your healthcare provider if you suspect any severe side effects.
✔️ Overdose and Missed Dose
Overdose:
If you accidentally take too much Letrozole, seek immediate medical attention
Missed dose:
Take the missed dose as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and take only the next one. Do not take extra or double doses to make up for the missed one.
✔️ Interactions
Food and drink interactions:
No known food or drink interactions with Letrozole. However, consuming alcohol may increase the risk of dizziness or drowsiness.
Drug interactions:
Inform your healthcare provider if you are taking:
- Tamoxifen (used to treat or prevent breast cancer)
- Estrogen medications, such as hormone replacement therapy or certain birth control pills
Always consult your doctor or pharmacist about possible interactions with other medications.
✔️ Pregnancy and breastfeeding:
- Do not use Letrozole if pregnant, as it can harm the fetus. Women of childbearing age should use effective contraception while taking Letrozole and for at least three weeks after the last dose.
- Breastfeeding is not recommended during treatment or for three weeks after the final dose.
✔️ Important considerations before using Letrozole:
- Discuss your medical history, including liver or kidney issues, high cholesterol, heart problems, or osteoporosis.
- Notify your healthcare provider if you are taking any prescription or over-the-counter medications, herbal supplements, or vitamins.
- Do not use Letrozole unless prescribed, and never share it with others.
- Letrozole may impair alertness or coordination. Avoid driving or operating machinery until you know how it affects you.
✔️ Storage:
Store Letrozole at room temperature (20°C to 25°C or 68°F to 77°F). It can temporarily tolerate temperatures between 15°C to 30°C (59°F to 86°F), such as during transport. Keep it in a cool, dry place.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
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